ATENOLOL 50 mg TABLETS

Atenolol tablets, as with other beta-blockers, should not be used in patients with any of the following: • hypersensitivity to the active substance or to any of the excipients listed in section 6.1. • second-degree or third-degree heart block. • bradycardia (<45 bpm). • Uncontrolled heart failure. • cardiogenic shock. • sick sinus syndrome. • untreated phaeochromocytoma. • severe p …

… . • Uncontrolled heart failure. • cardiogenic shock. • sick sinus syndrome. • untreated phaeochromocytoma. • severe peripheral arterial circulatory disturbances. • metabolic acidosis. • hypotension.

… • bradycardia (<45 bpm). • Uncontrolled heart failure. • cardiogenic shock. • sick sinus syndrome. • untreated phaeochromocytoma. • severe peripheral arterial circulatory disturbances. • metabolic acidosis. • hypotension.

… persensitivity to the active substance or to any of the excipients listed in section 6.1. • second-degree or third-degree heart block. • bradycardia (<45 bpm). • Uncontrolled heart failure. • cardiogenic shock. • sick sinus syndrome. • untreated phaeochromocytoma. • severe peripheral arterial circulatory disturbances. • metabolic acidosis. • hypotension.

Atenolol tablets, as with other beta-blockers, should not be used in patients with any of the following: • hypersensitivity to the active substance or to any of the excipients listed in section 6.1. • second-degree or third-degree heart block. • bradycardia (<45 bpm). • Uncontrolled heart failur …

… ion 6.1. • second-degree or third-degree heart block. • bradycardia (<45 bpm). • Uncontrolled heart failure. • cardiogenic shock. • sick sinus syndrome. • untreated phaeochromocytoma. • severe peripheral arterial circulatory disturbances. • metabolic acidosis. • hypotension.

… rcised if it is given to patients with first degree heart block. May mask the symptoms of hypoglycaemia, in particular tachycardia The signs of thyrotoxicosis may be masked by atenolol treatment. May cause a hypersensitivity reaction including angioedema and urticaria. Will reduce heart rate as a result of its pharmacological action. In the rare instances where a treated patient develops symptoms which may be attributable to a slow heart rate and the pulse drops …

… erly, starting with a lower dose (see section 4.2). Since atenolol is excreted via the kidneys, the dosage should be reduced in patients with a creatinine clearance of less than 35ml/minute/1.73m2. Although cardioselective (beta1) beta-blockers may have less effect on lung function than non-selective beta-blockers, as with all beta-blockers, these should be avoided in patients with reversible obstructive airways disease, unless there are compelling clinical reasons for their use. Where such reasons exist, atenolol may be used with caution. Occasionally, some increase in airways resistance may occur in asthmatic patients however, and this may usually be reversed by commonly used dosage of bronchodilators such as salbutamol or isoprenaline. The label and patient information leaflet for this product state the following warning: “If you have ever had asthma or wheezing, you should not take this medicine unless you have discussed these symptoms with the prescribing doctor”. As with other beta-blockers, in patients with a phaeochromocytoma, an alpha-blocker should be given concomitantly.

… aflet for this product state the following warning: “If you have ever had asthma or wheezing, you should not take this medicine unless you have discussed these symptoms with the prescribing doctor”. As with other beta-blockers, in patients with a phaeochromocytoma, an alpha-blocker should be given concomitantly.

… action. In the rare instances where a treated patient develops symptoms which may be attributable to a slow heart rate and the pulse drops to less than 50-55 bpm at rest, the dose should be reduced. Should be used with caution in the elderly, starting with a lower dose (see section 4.2). Since atenolol is excreted via the kidneys, the dosage should be reduced in patients with a creatinine clearance of less than 35ml/minute/1.73m2. Although cardioselective (beta1) beta-blockers may …

… uncontrolled heart failure (see section 4.3), atenolol may be used in patients whose signs of heart failure have been controlled. Caution must be exercised in patients whose cardiac reserve is poor. Beta-blockers may increase both the sensitivity towards allergens and the seriousness to patients with a history of anaphylactic reactions. Such patients may be unresponsive to the usual doses of adrenaline (epinephrine) used to treat the allergic reactions. Atenolol may increase the number and duration of angina attacks in patients with Prinzmetal's angina due to unopposed alpha receptor mediated coronary artery vasoconstriction. Atenolol is a beta1 se …

… erly, starting with a lower dose (see section 4.2). Since atenolol is excreted via the kidneys, the dosage should be reduced in patients with a creatinine clearance of less than 35ml/minute/1.73m2. Although cardioselective (beta1) beta-blockers may have less effect on lung function than non-selective beta-blockers, as with all beta-blockers, these should be avoided in patients with reversible obstructive airways disease, unless there are compelling clinical reasons for their use. Where such reasons exist, atenolol may be used with caution. Occasionally, some increase in airways resistance may occur in asthmatic patients however, and this may usually be reversed by commonly used dosage of bronchodilators such as salbutamol or isoprenaline. The label and patient information leaflet for this product state the following warning: “If you have ever had asthma or wheezing, you should not take this medicine unless you have discussed these symptoms with the prescribing doctor”. As with other beta-blockers, in patients with a phaeochromocytoma, an alpha-blocker should be given concomitantly.

… atenolol's negative effect on conduction time, caution must be exercised if it is given to patients with first degree heart block. May mask the symptoms of hypoglycaemia, in particular tachycardia The signs of thyrotoxicosis may be masked by atenolol treatment. May cause a hypersensitivity reaction including angioedema and urticaria. Will reduce heart rate as a result of its pharmacological action. In the rare instances where a treated patient develops s …

… with anaesthetic drugs may result in attenuation of the reflex tachycardia and increase the risk of hypotension. Anaesthetic agents causing myocardial depression are best avoided (see section 4.4). Anti-arrhythmics: Class I anti-arrhythmic drugs (e.g. disopyramide) and amiodarone may have a potentiating effect on atrial-conduction time and induce negative inotropic effect. Antidiabetics: Concomitant use wi …

Caution should be exercised when atenolol is administered during pregnancy or to a woman who is breast-feeding. Pregnancy: Atenolol crosses the placental barrier and appears in the cord blood. No studies have been performed on the use of atenolol in the first trimester and the possibility of foetal injury …

… ent of hypertension in the third trimester. Administration of atenolol to pregnant women in the management of mild to moderate hypertension has been associated with intra-uterine growth retardation. The use of atenolol in women who are, or may become, pregnant requires that the anticipated benefit be weighed against the possible risks, particularly in the first and second trimesters, since beta-blockers, in general, have been associated with a decrease in placental perfusion which may result in growth retardation, intra-uterine deaths, abortion, immature and premature deliveries. Breast-feeding: There is significant accumulation of atenolol in breast milk. Neonates born to mothers who are receiving atenolol at parturition or breast- feeding may be at risk of hypoglycaemi …

… perfusion which may result in growth retardation, intra-uterine deaths, abortion, immature and premature deliveries. Breast-feeding: There is significant accumulation of atenolol in breast milk. Neonates born to mothers who are receiving atenolol at parturition or breast- feeding may be at risk of hypoglycaemia and bradycardia.

Caution should be exercised when atenolol is administered during pregnancy or to a woman who is breast-feeding. Pregnancy: Atenolol crosses the placental barrier and appears in the cord blood. No studies have been performed on the use of atenolol in the first trimester and the possibility of foetal injury …

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