… alone. Limit the dose of simvastatin in patients on amlodipine to 20 mg daily.
In clinical interaction studies, amlodipine did not affect the pharmacokinetics of atorvastatin, digoxin or warfarin.
A dose of 5 mg of Amlodipine oral solution administered to (a child 7 years of age and weighing approximately 23 kg or a dose of 10 mg of Amlodipine oral solution administered to an adult weighing 70 kg) would result in exposure to 4.51 mg/kg (adults an adult weighing 70 kg) and 6.87 mg (a child 7 years of age and weighing) of ethanol which may cause a rise in blood alcohol concentration (BAC) of about 0.7 mg/100 ml (adults an adult weighing 70 kg) or .009 mg/100 ml (a child 7 years of age and weighing).
For comparison, for an adult drinking a glass of wine or 500 ml of beer, the BAC is likely to be about 50 mg/100 ml.
Co-administration with medicines containing e.g. propylene glycol or ethanol may …