… e risk of ulceration or bleeding, such as oral corticosteroids, or anticoagulants such as warfarin, selective serotonin-reuptake inhibitors or anti-platelet agents such as aspirin (see section 4.5).
Caution should be taken when using ibuprofen with excessive alcohol or heavy alcohol drinkers. Alcohol may increase the risk of gastrointestinal bleeding.
When GI bleeding or ulceration occurs in patients receiving ibuprofen, the treatment should be withdrawn.
Immune system:
Ibuprofen may cause severe allergic reactions including very rare cases …
… be observed carefully.
In case of long-term treatment with ibuprofen a periodical monitoring of hepatic and renal function as well as the blood count is necessary, especially in high risk patients.
Consumption of alcohol should be avoided since it may intensify side effects of NSAIDs, especially if affecting the gastrointestinal tract or the central nervous system.
Patients on ibuprofen should report to their doctor signs or symptoms of gastro-intestinal ulceration or bleeding, blurred vision or other eye symptoms, skin rash, weight gain or oedema.
Paediatri …
… upon withdrawal of treatment.
• Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.
• Consumption of alcohol should be avoided during treatment.
• Pseudoephedrine hydrochloride may cause a positive reaction in tests conducted during anti-doping checks.