… hematosus (SLE) or mixed connective tissue diseases. - Congenital disturbance of porphyrin metabolism (e.g. acute intermittent porphyria) - The first and second trimester of pregnancy - Lactation
Special care has to be taken in the following cases: - Gastrointestinal diseases including chronic inflammatory intestinal disease (ulcerative colitis, Crohn's disease) - Cardiac insufficiency and hypertension - Reduced renal function - Hepatic dysfunction - Disturbed haematopoiesis - Blood coagulation defects - Allergies, hay fever, chronic swelling of nasal mucosa, adenoids, chronic obstructive airway disease or bronchial asthma - Immediately after major surgical interventions
Gastrointestinal bleeding, ulceration and perforation
GI bleeding, ulceration or perforation, which can be fatal, has been reported with all NSAIDs at anytime during treatment, with or without wa …