… ol drinkers. Alcohol may increase the risk of gastrointestinal bleeding.
When GI bleeding or ulceration occurs in patients receiving ibuprofen, the treatment should be withdrawn.
Immune system:
Ibuprofen may cause severe allergic reactions including very rare cases of anaphylaxis (see section 4.8). Symptoms may include hives, facial swelling, asthma (wheezing), shock, skin reddening, rash or blisters. If any of these symptoms occur, patients should stop use and seek medical help right away.
Severe cutaneous adverse reactions (SCARs):
Severe cutaneous adverse reactions (SCARs), including exfoliative dermatitis, erythema multiforme, Stevens-Johnson Syndrome (SJS) and Toxic Epidermal …
… ly to occur in patients with systemic lupus erythematosus and related connective tissue diseases, it has been reported in patients who do not have an underlying chronic disease.
Other precautions
Severe acute hypersensitivity reactions (for example anaphylactic shock) are observed very rarely. At the first signs of hypersensitivity reaction after taking/administering ibuprofen therapy must be stopped. Medically required measures, in line with the symptoms, must be initiated by specialist personnel.
Bronchospasm, urticaria or angioedema may be precipitated in patients suffering from or with a previous history of bronchial asthma, chronic rhinitis, sinusitis, nasal polyps, adenoids or allergic d …