Metrogel 0.75% w/w Gel

Concepts (30)

• +Liver conditionsContraindicated

  Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. Metronidazole must not be used in patients with Cockayne syndrome. Cases of severe hepatotoxicity/acute hepatic failure, including cases with a fatal outcome with very rapid onset after treatment initiation in patients with Cockayne syndrome have been reported with products containing metronidazole for systemic use.

  Source SmPC ↗
• +Allergy to the medicineContraindicated

  Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. Metronidazole must not be used in patients with Cockayne syndrome. Cases of severe hepatotoxicity/acute hepatic failure, including cases with a fatal outcome with very rapid onset after treatment in …

  Source SmPC ↗
• +Benzyl alcoholWarning

  … d prolonged use of this medication should be avoided. Evidence suggests that metronidazole is carcinogenic in certain animal species. There is no evidence to date of a carcinogenic effect in human. This product contains 50 mg of propylene glycol (E1520) in each gram which is equivalent to 5% w/w and may cause skin irritation. This product also contains hydroxybenzoic acid esters which may cause allergic reactions (possibly delayed) and bronopol which may cause local skin reactions (e.g. contact dermatitis).

  Source SmPC ↗
• +Propylene glycolWarning

  … d prolonged use of this medication should be avoided. Evidence suggests that metronidazole is carcinogenic in certain animal species. There is no evidence to date of a carcinogenic effect in human. This product contains 50 mg of propylene glycol (E1520) in each gram which is equivalent to 5% w/w and may cause skin irritation. This product also contains hydroxybenzoic acid esters which may cause allergic reactions (possibly delayed) and bronopol which may cause local skin reactions (e.g. contact dermatitis).

  Source SmPC ↗
• +UnclassifiedWarning

  Contact with mucous membranes should be avoided. Metrogel has been reported to cause lacrimation of the eyes, therefore, contact with the eyes should be avoided. If a reaction suggesting local irritation occurs patients should be directed to use t …

  Source SmPC ↗
• +AlcoholInteraction

  Interaction with systemic medication is unlikely because absorption of metronidazole following cutaneous application of Metrogel is low. Nevertheless, it should be mentioned that disulfiram-like reactions have been reported in a small number of patients taking metronidazole and alcohol concomitantly. Oral metronidazole has been reported to potentiate the effect of warfarin and other coumarin anticoagulants, resulting in a prolongation of prothrombin time. The effect of topical metronidazole on prothrombin is not known. However, very rare cases of modification of the INR values have been reported with concomitant use of Metrogel and coumarin anticoagulants.

  Source SmPC ↗
• +Taken with other medicinesInteraction

  Interaction with systemic medication is unlikely because absorption of metronidazole following cutaneous application of Metrogel is low. Nevertheless, it should be mentioned that disulfiram-like reactions have been reported in a small number of patients taking metronidazole and alcohol concomitantly. Oral metronidazole has been reported to potentiate the effect of warfarin and other coumarin anticoagulants, resulting in a prolongation of prothrombin time. The effect of topical metronidazole on prothrombin is not known. However, very rare cases of modification of the INR values have been reported with concomitant use of Metrogel and coumarin anticoagulants.

  Source SmPC ↗
• +BreastfeedingPregnancy

  … tion studies are not always predictive of human response and since oral metronidazole has been shown to be a carcinogen in some rodents this drug should be used in pregnancy only if clearly needed. Breast-feeding After oral administration metronidazole is secreted in breast milk in concentration similar to those found in plasma. Even though blood levels are significantly lower with cutaneous application of …

  Source SmPC ↗
• +PregnancyPregnancy

  Pregnancy There has been no experience to date with the use of Metrogel in pregnant patients. In case of oral administration, metronidazole crosses the placental barrier and enters foetal circulation rapidly …

  Source SmPC ↗
• +Bleeding risk—Not in scanned sections

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• +Intolerance to an ingredient—Not in scanned sections

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• +Dialysis and blood filtering—Not in scanned sections

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• +Fertility—Not in scanned sections

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• +Stomach and gut—Not in scanned sections

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• +Blood disorders—Not in scanned sections

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• +Heart rhythm block—Not in scanned sections

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• +Low blood pressure—Not in scanned sections

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• +Infection—Not in scanned sections

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• +Lactose—Not in scanned sections

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• +Cancer—Not in scanned sections

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• +Sodium and potassium content—Not in scanned sections

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• +Blockage—Not in scanned sections

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• +Children—Not in scanned sections

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• +Sugar alcohols—Not in scanned sections

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• +Porphyria—Not in scanned sections

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• +Heart rhythm (QT interval)—Not in scanned sections

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• +Kidney conditions—Not in scanned sections

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• +Shock—Not in scanned sections

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• +Blood vessel conditions—Not in scanned sections

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• +Wheat starch—Not in scanned sections

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