… which may not respond to continued aciclovir treatment (see section 5.1).
Hydration status: Care should be taken to maintain adequate hydration in patients receiving high oral doses of aciclovir.
The risk of renal impairment is increased by use with other nephrotoxic drugs.
The data currently available from clinical studies is not sufficient to conclude that treatment with aciclovir reduces the incidence of chickenpox-associated complications in immunocompetent patient …
Identical in all 3 labels. Surrounding text shown from Ranbaxy (UK) Limited a Sun Pharmaceutical Company.
… ons of aciclovir are alkaline (pH of approximately 11) and intended for intravenous infusion only and should not be used by any other route.
Contact with eyes or unprotected skin should be avoided.
Although the aqueous solubility of aciclovir exceeds 100 mg/ml, precipitation of aciclovir crystals in renal tubules and the consequent renal tubular damage can occur if the maximum solubility of free aciclovir (2.5 mg/ml at 37°C in water) is exceeded. Infusions of aciclovir must be given over a period of at least one hour in order to avoid renal tubular damage. Rapid or bolus injection should be avoided. Aciclovir infusions must be accompanied by adequate hydration. Since maximum urine concentration occurs within the first few hours following infusion particular attention should be given to establish sufficient urine flow during that period. Concomitant use of other nephrotoxic drugs, pre-existing renal disease and dehydration increase the risk of further renal impairment by aciclovir.
Use in patients with renal impairment and in elderly patients:
Aciclovir is eliminated by renal clearance, therefore the dose must be adjusted in patients with renal impairment (see section 4.2). …
… cavity, eye, vagina) since local reactions may occur. Particular care should be taken to avoid accidental introduction into the eye.
Patients with severe Herpes Labialis should seek medical advice.
In severely immunocompromised patients (e.g. AIDS patients or bone marrow transplant recipients) oral aciclovir dosing should be considered. Such patients should be encouraged to consult their physician concerning the treatment of any infection and before starting treatment with Virasorb Cold Sore Cream.
Virasorb Cold Sore Cream must not be used for treatment of ocular herpes infections or for the treatment of genital herpes.
Excipient Warnings:
• This medicine contains cetyl alcohol which may ca …
Severe cutaneous adverse reactions:
Cases of severe cutaneous adverse reactions (SCARs), including toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome (SJS), acute generalized exanthematous pustulosis (AGEP), drug reaction with eosinophilia and systemic symptoms (DRESS) and erythema multiforme (EM) have been reported in patients treated with aciclovir.
As SCARs can be life-threatening or fatal, if signs and symptoms suggestive of SCARs appear, treatment with aciclovir must be discontinued immediately, and alternative treatment should be given. Pa …