Anadin Extra P

… or to any other excipients. - Patients in whom asthma, bronchospasm, angioedema, urticaria, or acute rhinitis are precipitated by aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs). - Peptic ulceration and those with a history of peptic ulceration; - History of upper gastrointestinal bleeding or perforation, related to previous NSAID therapy. - History of hemophilia, hypothrombinemia or other clotting disorders - Renal failure (GFR < 15mL/ …

… upper gastrointestinal bleeding or perforation, related to previous NSAID therapy. - History of hemophilia, hypothrombinemia or other clotting disorders - Renal failure (GFR < 15mL/min/1.73m2). - Hepatic failure. - Third trimester of pregnancy children under 16 years and when breast feeding because of possible risk of Reyes Syndrome.

This combination is contraindicated in the following conditions: - Hypersensitivity to the active ingredients or to any other excipients. - Patients in whom asthma, bronchospasm, angioedema, urticaria, or acute rhinitis are precipitated by aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs). - Peptic ulceration and those …

… , angioedema, urticaria, or acute rhinitis are precipitated by aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs). - Peptic ulceration and those with a history of peptic ulceration; - History of upper gastrointestinal bleeding or perforation, related to previous NSAID therapy. - History of hemophilia, hypothrombinemia or other clotting disorders - Renal failure (GFR < 15mL/min/1.73m2). - Hepatic failure. - Third trimester of pregnancy children under 16 years and when …

… lated to previous NSAID therapy. - History of hemophilia, hypothrombinemia or other clotting disorders - Renal failure (GFR < 15mL/min/1.73m2). - Hepatic failure. - Third trimester of pregnancy children under 16 years and when breast feeding because of possible risk of Reyes Syndrome.

… al bleeding or perforation, related to previous NSAID therapy. - History of hemophilia, hypothrombinemia or other clotting disorders - Renal failure (GFR < 15mL/min/1.73m2). - Hepatic failure. - Third trimester of pregnancy children under 16 years and when breast feeding because of possible risk of Reyes Syndrome.

… tory of peptic ulceration; - History of upper gastrointestinal bleeding or perforation, related to previous NSAID therapy. - History of hemophilia, hypothrombinemia or other clotting disorders - Renal failure (GFR < 15mL/min/1.73m2). - Hepatic failure. - Third trimester of pregnancy children under 16 years and when breast feeding because of possible risk of Reyes Syndrome.

This combination is contraindicated in the following conditions: - Hypersensitivity to the active ingredients or to any other excipients. - Patients in whom asthma, bronchospasm, angioedema, urticaria, or acute rhinitis are precipitated by aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs). - Peptic ulceration and those with a history of peptic ulceration; - History of upper gastrointestinal bleeding or perforation, related to previous NSAID therapy. - History of hemophilia, hypothr …

This combination is contraindicated in the following conditions: - Hypersensitivity to the active ingredients or to any other excipients. - Patients in whom asthma, bronchospasm, angioedema, urticaria, or acute rhinitis are precipitated by aspirin or other non-s …

Serious hypersensitivity reactions or anaphylaxis can occur, bronchospasm may be precipitated in patients suffering from or with a previous history of asthma, allergic disease or nasal polyps. Aspirin should be used with caution in patients with uncontrolled hypertension (in whom target blood pressure has not been achieved), impaired renal or hepatic function, or in patients who are dehydrated or suffering from diabetes mellitus. The overall benefit-risk should be considered in patients diagnosed with hepatic or renal impairment before use. The hazards of overdose are greater in those with non-cirrhotic alcoholic liver disease. Contains paracetamol. Do not use with any other paracetamol containing products. The concomitant use with other products containing paracetamol may lead to an overdose. Do not take if you have a st …

… overall benefit-risk should be considered in patients diagnosed with hepatic or renal impairment before use. The hazards of overdose are greater in those with non-cirrhotic alcoholic liver disease. Contains paracetamol. Do not use with any other paracetamol containing products. The concomitant use with other products containing paracetamol may lead to an overdose. Do not take if you have a stomach ulcer. Do not take more medicine than the label tells you to. Paracetamol overdose may cause liver failure which may require liver transplant or lead to death. Tal …

… lucose-6-phosphate dehydrogenase (G6PD) deficiency, aspirin may induce haemolysis or haemolytic anaemia. Factors that may increase the risk of haemolysis are high dosage, fever, or acute infections. Gastrointestinal bleeding, ulceration or perforation, which can be fatal, have been reported with all NSAIDs and may occur at any time during treatment, with or without warning symptoms or a previous history of serious GI events. These effects generally have more serious consequences in the elderly (see Interactions) Cases of hepatic dysfunction/failure have been reported in patients with depleted glutathione levels, such as those who are severely malnourished, anorexic, have a low body mass index or are chronic …

… ases platelet adhesiveness and increases bleeding time. Haematological and haemorrhagic effects can occur and may be severe. Patients should report any unusual bleeding symptoms to their physician. In patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, aspirin may induce haemolysis or haemolytic anaemia. Factors that may increase the risk of haemolysis are high dosage, fever, or acute infections. Gastrointestinal bleeding, ulceration or perforation, which can be fatal, have been reported with all NSAIDs and may occur at any time during treatment, with or without warning symptoms or a previou …

… ases platelet adhesiveness and increases bleeding time. Haematological and haemorrhagic effects can occur and may be severe. Patients should report any unusual bleeding symptoms to their physician. In patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, aspirin may induce haemolysis or haemolytic anaemia. Factors that may increase the risk of haemolysis are high dosage, fever, or acute infections. Gastrointestinal bleeding, ulceration or perforation, which can be fatal, have been reported with all NSAIDs and may occur at any time during treatment, with or without warning symptoms or a previou …

… of paracetamol- related liver damage. The overall benefit-risk should be considered in patients diagnosed with hepatic or renal impairment before use. If you do not get better, talk to your doctor. There is a possible association between aspirin and Reye's syndrome when given to children, especially during or immediately after a viral illness. Reye's syndrome is a very rare disease, which affects the brain and liver, and can be fatal. For this reason, aspirin should not be given to children under 16 years, particularly during or immediately after chickenpox, influenza, or other viral infections, unless prescribed by a physician or specifically indicated (e.g. Kawasaki's disease). Aspirin decreases platelet adhesiveness and increases bleeding time. Haematological and haemorrhagic effects can occur and may be severe. Patients should report any unusual bleeding symptoms to thei …

… e been reported in patients with depleted glutathione levels, such as those who are severely malnourished, anorexic, have a low body mass index or are chronic heavy users of alcohol or have sepsis. In patients with glutathione depleted states, the use of paracetamol may increase the risk of metabolic acidosis. Keep out of sight and reach of children Should be used with caution in elderly patients who are more prone to adverse events. The concomitant use of aspirin with other systemic NSAIDs, including c …

… istered simultaneously with aspirin, it is necessary to ensure adequate hydration of the patient and to monitor the kidney function and blood pressure, particularly when starting diuretic treatment. Like other NSAIDs, concomitant use of aspirin with diuretics or antihypertensive agents (e.g., beta-blockers, angiotensin converting enzyme (ACE) inhibitors) may cause a decrease in their antihypertensive effect. Therefore, the combination should be administered with caution and patients, especially the elderly, should have their blood pressure periodically monitored. Patients should be adequately hydrated and consideration should be given to monitoring of renal function after initiation of concomitant therapy and periodically thereafter, particularly for diuretics and ACE inhibitors, due to the increased risk of nephrotoxicity. Concomitant treatment with potassium-sparing drugs may be associated with increased serum potassium levels, which should therefore be monitored frequently. Anticoagulants: Aspirin may enhance the effects of oral anticoagulants, such as heparin and coumarins, and of platelet aggregation inhibitors, such as ticlopidine, clopidogrel, and cilostazol, as th …

… nded. Alcohol: Co-administration of alcohol and aspirin increases the risk of gastrointestinal haemorrhage. Antacids: Antacids may increase the excretion of aspirin by alkalinization of the urine. Selective Serotonin Re-Uptake Inhibitors (SSRIs): Concurrent use of aspirin and SSRIs can increase the risk of gastrointestinal bleeding. Paracetamol: Cholestyramine: The speed of absorption of paracetamol is reduced by cholestyramine. Therefore, the cholestyramine should not be taken within one hour if maximal analgesia is requir …

… at the lowest possible frequency. Caffeine: Caffeine is not recommended for use during pregnancy due to the possible increased risk of spontaneous abortion associated with caffeine consumption. Lactation Aspirin Aspirin appears in breast milk, and regular high doses may affect neonatal clotting. Not recommended while breast-feeding due to possible risk of Reye's Syndrome as well as neonatal bleedi …

Fertility Aspirin There is some evidence that medicinal products that inhibit cyclo-oxygenase / prostaglandin synthesis may cause impairment of female fertility by an effect on ovulation. This is reversible …

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