Aspirin 300

Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. Hypoprothrombinaemia, haemophilia, haemorrhagic disease or a history of bleeding disorders, cerebral haemorrhage and active peptic ulceration or a history of peptic ulceration. Third trimester of pregnancy (see section 4.6). In women who are breastfeeding (see section 4.6).

Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. Hypoprothrombinaemia, haemophilia, haemorrhagic disease or a history of bleeding disorders, cerebral haemorrhage and active peptic ulceration or a history of peptic ulceration. Third trimester of …

… ted in section 6.1. Hypoprothrombinaemia, haemophilia, haemorrhagic disease or a history of bleeding disorders, cerebral haemorrhage and active peptic ulceration or a history of peptic ulceration. Third trimester of pregnancy (see section 4.6). In women who are breastfeeding (see section 4.6).

… th glucose 6-phosphate dehydrogenase (G6PD) deficiency. Aspirin should be used with caution in patients with impaired renal or hepatic function (avoid if severe), or in patients who are dehydrated. Nu-seals 300mg contains benzyl alcohol. High volumes should be used with caution and only if necessary, especially in patients with liver or kidney impairment because of the risk of benzyl alcohol accumulation and toxicity (metabolic acidosis). Benzyl alcohol may also cause allergic reactions. Patients with hypertension should be carefully monitored. Nu-Seals should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity. There is som …

… th glucose 6-phosphate dehydrogenase (G6PD) deficiency. Aspirin should be used with caution in patients with impaired renal or hepatic function (avoid if severe), or in patients who are dehydrated. Nu-seals 300mg contains benzyl alcohol. High volumes should be used with caution and only if necessary, especially in patients with liver or kidney impairment because of the risk of benzyl alcohol accumulation and toxicity (metabolic acidosis). Benzyl alcohol may also cause allergic reactions. Patients with hypertension should be carefully monitored. Nu-Seals should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity. There is som …

… e or coagulation abnormalities as they may also induce gastro-intestinal haemorrhage, occasionally major. They may also precipitate bronchospasm or induce attacks of asthma in susceptible subjects. High doses of aspirin may precipitate acute haemolytic anaemia in patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency. Aspirin should be used with caution in patients with impaired renal or hepatic function (avoid if severe), or in patients who are dehydrated. Nu-seals 300mg contains benzyl alcohol. High volumes sh …

… c reactions. Patients with hypertension should be carefully monitored. Nu-Seals should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity. There is some evidence that drugs which inhibit cyclo-oxygenase/prostaglandin synthesis may cause impairment of female fertility by an effect on ovulation. This is reversible on withdrawal of treatment (see section 4.6).

… e or coagulation abnormalities as they may also induce gastro-intestinal haemorrhage, occasionally major. They may also precipitate bronchospasm or induce attacks of asthma in susceptible subjects. High doses of aspirin may precipitate acute haemolytic anaemia in patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency. Aspirin should be used with caution in patients with impaired renal or hepatic function (avoid if severe), or in patients who are dehydrated. Nu-seals 300mg contains benzyl alcohol. High volumes sh …

There is a possible association between aspirin and Reye's syndrome when given to children. Reye's syndrome is a very rare disease, which affects the brain and liver, and can be fatal. For this reason, aspirin should not be given to children aged under 16 years unless specifically indicated (e.g. for Kawasaki's disease). Aspirin can reduce uric acid excretions and therefore should be used with care in patients with gout or a history of gout. Before commencing long-term aspirin therapy for the management of cerebrov …

… th glucose 6-phosphate dehydrogenase (G6PD) deficiency. Aspirin should be used with caution in patients with impaired renal or hepatic function (avoid if severe), or in patients who are dehydrated. Nu-seals 300mg contains benzyl alcohol. High volumes should be used with caution and only if necessary, especially in patients with liver or kidney impairment because of the risk of benzyl alcohol accumulation and toxicity (metabolic acidosis). Benzyl alcohol may also cause allergic reactions. Patients with hypertension should be carefully monitored. Nu-Seals should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity. There is som …

There is a possible association between aspirin and Reye's syndrome when given to children. Reye's syndrome is a very rare disease, which affects the brain and liver, and can be fatal. For this reason, aspirin should not be given to children aged under 16 years unless specifically indicated (e.g. for Kawasaki's disease). Aspirin can reduce uric acid excretions and therefore should be used with care in patients with gout or a history of gout. Before commencing long-term aspirin therapy for the management of cerebrov …

… ronchospasm or induce attacks of asthma in susceptible subjects. High doses of aspirin may precipitate acute haemolytic anaemia in patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency. Aspirin should be used with caution in patients with impaired renal or hepatic function (avoid if severe), or in patients who are dehydrated. Nu-seals 300mg contains benzyl alcohol. High volumes should be used with caution and only if necessary, especially in patients with liver or kidney impairment because of the risk of benzyl alcohol a …

… hysician. Salicylates should be used with caution in patients with inflammatory bowel disease or coagulation abnormalities as they may also induce gastro-intestinal haemorrhage, occasionally major. They may also precipitate bronchospasm or induce attacks of asthma in susceptible subjects. High doses of aspirin may precipitate acute haemolytic anaemia in patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency. Aspirin should be used with caution in patients with impaired re …

… isease, which affects the brain and liver, and can be fatal. For this reason, aspirin should not be given to children aged under 16 years unless specifically indicated (e.g. for Kawasaki's disease). Aspirin can reduce uric acid excretions and therefore should be used with care in patients with gout or a history of gout. Before commencing long-term aspirin therapy for the management of cerebrovascular or cardiovascular disease patients should consult their doctor who can advise on the relative benefits versus the ri …

Metamizole may reduce the effect of acetylsalicylic acid on platelet aggregation, when taken concomitantly. Therefore, this combination should be used with caution in patients taking low dose aspirin for cardioprotection. Salicylates may enhance the effect of oral hypoglycaemic agents, phenytoin and sodium valproate. They inhibit the uricosuric effect of probenecid and may increase the toxicity of sulphonamides. A …

… c acid, 17-hydroxycorticosteroids, 5-hydroxyindoleacetic acid, urine pregnancy tests and with some serum or plasma tests for albumin, barbiturates, calcium, propylthiouracil, tyrosine and uric acid. Anti-platelet agents and selective serotonin reuptake inhibitors (SSRIs): increased risk of gastrointestinal bleeding.

… ce regarding the use of doses above 100 mg/day up to 500 mg/day. Therefore, the recommendation below for doses of 500 mg/day and above apply also for this dose range. Doses of 500 mg/day and above: Inhibition of prostaglandin synthesis may adversely affect the pregnancy and/or the embryo/foetal development. Data from epidemiological studies suggest an increased risk of miscarriage and of cardiac malformation and gastroschisis after use of a prostaglandin synthesis inhibitor in early pregnancy. The absolute risk for cardiovascular malformation was increased from less than 1%, up to approximately 1.5%. The risk is believed to increase with dose and duration of therapy. In animals, administration of prostaglandin synthesis inhibitor has been shown to results in increased pre- and post-implantation loss and embryo-foetal lethality. In addition, increased incidences of various malformations, including cardiovascular, have been reported in animals given a prostaglandin synthesis inhibitor during the organogenetic period. From the 20th week of pregnancy onward, acetylsalicylic acid use may cause oligohydramnios resulting from foetal renal dysfunction. This may occur shortly after treatment initiation and is usually reversible upon discontinuation. In addition, there have been reports of ductus arteriosus constriction following treatment in the second trimester, most of which resolved after treatment cessation. Therefore, during the first and second trimester of pregnancy, acetylsalicylic acid should not be given unless clearly necessary. If acetylsalicylic acid is used by a woman attempting to conceive, or during the first and second trimester of pregnancy, the dose should be kept as low and duration of treatment as short as possible. Antenatal monitoring for oligohydramnios and ductus arteriosus constriction should be considered after exposure to acetylsalicylic acid for several days from gestational week 20 onward. Acetylsalicylic acid should be discontinued if oligohydramnios or ductus arteriosus constriction are found. During the third trimester of pregnancy, all prostaglandin synthesis inhibitors may expose the foetus to: - cardiopulmonary toxicity (premature constriction/closure of the ductus arteriosus and pul …

Maize Starch Hypromellose Talc Methacrylic acid – ethyl acrylate (1:1) copolymer dispersion 30 per cent Polyethylene Glycol 3350 Propylene Glycol Benzyl Alcohol Emulsion silicone Printing Ink – containing shellac, iron oxide (E172), isopropyl alcohol, n-butyl alcohol, propylene glycol, ammonium hydroxide (E527) and simeticone

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