Aspirin Suppositories 150mg

Concepts (37)

• +Angioedema (deep swelling)Contraindicated

  • Known hypersensitivity to aspirin, other ingredients in the product, other salicylates or non-steroidal anti-inflammatory drugs (a patient may have developed anaphylaxis, angioedema, asthma, rhinitis or urticaria induced by aspirin or other NSAIDs). • Nasal polyps associated with asthma (high risk of severe sensitivity reactions). • Active peptic ulceration or a past history of ulceration or dyspepsia. • Haemophilia or other haemorrhagic d …

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• +Bleeding riskContraindicated

  … nduced by aspirin or other NSAIDs). • Nasal polyps associated with asthma (high risk of severe sensitivity reactions). • Active peptic ulceration or a past history of ulceration or dyspepsia. • Haemophilia or other haemorrhagic disorder (including thrombocytopenia) as there is an increased risk of bleeding. • Concurrent anticoagulant therapy should be avoided. • Severe hepatic impairment • Severe renal impairment • Severe cardiac failure • Third trimester of pregnancy • Methotrexate used at …

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• +Heart conditionsContraindicated

  … disorder (including thrombocytopenia) as there is an increased risk of bleeding. • Concurrent anticoagulant therapy should be avoided. • Severe hepatic impairment • Severe renal impairment • Severe cardiac failure • Third trimester of pregnancy • Methotrexate used at doses >15mg/week (see section 4.5). • Children under 16 years old, unless specifically indicated (e.g. Kawasaki's disease).

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• +Stomach and gutContraindicated

  … may have developed anaphylaxis, angioedema, asthma, rhinitis or urticaria induced by aspirin or other NSAIDs). • Nasal polyps associated with asthma (high risk of severe sensitivity reactions). • Active peptic ulceration or a past history of ulceration or dyspepsia. • Haemophilia or other haemorrhagic disorder (including thrombocytopenia) as there is an increased risk of bleeding. • Concurrent anticoagulant therapy should be avoided. • Severe hepatic impai …

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• +Blood disordersContraindicated

  … nduced by aspirin or other NSAIDs). • Nasal polyps associated with asthma (high risk of severe sensitivity reactions). • Active peptic ulceration or a past history of ulceration or dyspepsia. • Haemophilia or other haemorrhagic disorder (including thrombocytopenia) as there is an increased risk of bleeding. • Concurrent anticoagulant therapy should be avoided. • Severe hepatic impairment • Severe renal impairment • Severe cardiac failure • Third trimester of pregnancy • Methotrexate used at …

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• +Liver conditionsContraindicated

  … ration or dyspepsia. • Haemophilia or other haemorrhagic disorder (including thrombocytopenia) as there is an increased risk of bleeding. • Concurrent anticoagulant therapy should be avoided. • Severe hepatic impairment • Severe renal impairment • Severe cardiac failure • Third trimester of pregnancy • Methotrexate used at doses >15mg/week (see section 4.5). • Children under 16 years old, unless specifical …

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• +Allergy to the medicineContraindicated

  • Known hypersensitivity to aspirin, other ingredients in the product, other salicylates or non-steroidal anti-inflammatory drugs (a patient may have developed anaphylaxis, angioedema, asthma, rhinitis or urticaria induced by aspirin or other NSAIDs). • Nasal polyps associated with asthma (high risk of severe sensitivity reactions). • Active peptic ulceration or a past history of ulceration or dyspepsia. • Haemophilia or other haemorrhagic d …

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• +ChildrenContraindicated

  … ould be avoided. • Severe hepatic impairment • Severe renal impairment • Severe cardiac failure • Third trimester of pregnancy • Methotrexate used at doses >15mg/week (see section 4.5). • Children under 16 years old, unless specifically indicated (e.g. Kawasaki's disease).

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• +PregnancyContraindicated

  … ocytopenia) as there is an increased risk of bleeding. • Concurrent anticoagulant therapy should be avoided. • Severe hepatic impairment • Severe renal impairment • Severe cardiac failure • Third trimester of pregnancy • Methotrexate used at doses >15mg/week (see section 4.5). • Children under 16 years old, unless specifically indicated (e.g. Kawasaki's disease).

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• +Kidney conditionsContraindicated

  … philia or other haemorrhagic disorder (including thrombocytopenia) as there is an increased risk of bleeding. • Concurrent anticoagulant therapy should be avoided. • Severe hepatic impairment • Severe renal impairment • Severe cardiac failure • Third trimester of pregnancy • Methotrexate used at doses >15mg/week (see section 4.5). • Children under 16 years old, unless specifically indicated (e.g. Kawasaki' …

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• +Breathing conditionsContraindicated

  • Known hypersensitivity to aspirin, other ingredients in the product, other salicylates or non-steroidal anti-inflammatory drugs (a patient may have developed anaphylaxis, angioedema, asthma, rhinitis or urticaria induced by aspirin or other NSAIDs). • Nasal polyps associated with asthma (high risk of severe sensitivity reactions). • Active peptic ulceration or a past history of ulceration or dyspepsia. • Haemophilia or other haemorrhagic d …

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• +UnclassifiedContraindicated

  … . • Active peptic ulceration or a past history of ulceration or dyspepsia. • Haemophilia or other haemorrhagic disorder (including thrombocytopenia) as there is an increased risk of bleeding. • Concurrent anticoagulant therapy should be avoided. • Severe hepatic impairment • Severe renal impairment • Severe cardiac failure • Third trimester of pregnancy • Methotrexate used at doses >15mg/week (see section 4.5). • Children under 1 …

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• +Taken with other medicinesWarning

  … hydrated since the use of NSAIDs may result in deterioration of renal function. Liver function tests should be performed regularly in patients presenting slight or moderate hepatic insufficiency. • There is an increased risk of haemorrhage particularly during or after operative procedures (even in cases of minor procedures, e.g. tooth extraction). Use with caution before surgery, including tooth extraction. Temporary discontinuation of treatment may be necessary. • Systemic lupus erythematosus and other connective tissue disorders (hepatic and renal function may be impaired in these conditions) • Thyrotoxicosis (may be exacerbated by large doses of salicy …

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• +DehydrationWarning

  … r substances (e.g. with skin reactions, itching or urticaria). • Anaemia (may be exacerbated by gastrointestinal blood loss) • Cardiac failure (conditions which predispose to fluid retention) • Dehydration • Glucose-6-phosphate dehydrogenase deficiency (aspirin rarely causes haemolytic anaemia) • Gout (serum urate may be increased) • Acetylsalicylic acid should be used with caution in patients wi …

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• +Older peopleWarning

  … ic lupus erythematosus and other connective tissue disorders (hepatic and renal function may be impaired in these conditions) • Thyrotoxicosis (may be exacerbated by large doses of salicylates) • Elderly patients are particularly susceptible to the adverse effects of NSAIDs, including acetylsalicylic acid especially gastrointestinal bleeding and perforation which may be fatal (see section 4.2). Where prolonged therapy is required, patients should be reviewed regularly. • Before commencing long-term aspirin therapy for the management of cardiovascular or cerebrovascular disease patients should consult their doctor who can advise on the relative benefits versus the …

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• +Enzyme deficiencyWarning

  … g. with skin reactions, itching or urticaria). • Anaemia (may be exacerbated by gastrointestinal blood loss) • Cardiac failure (conditions which predispose to fluid retention) • Dehydration • Glucose-6-phosphate dehydrogenase deficiency (aspirin rarely causes haemolytic anaemia) • Gout (serum urate may be increased) • Acetylsalicylic acid should be used with caution in patients with moderately impaired renal or hepatic function (contraindicated if severe), or in patients …

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• +VaccinationWarning

  … n therapy for the management of cardiovascular or cerebrovascular disease patients should consult their doctor who can advise on the relative benefits versus the risks for the individual patient. • Vaccine recipients should avoid use of salicylates for 6 weeks after varicella vaccination (see section 4.5). • Acetylsalicylic acid is not recommended during menorrhagia where it may increase menstrual bleeding. • Acetylsalicylic acid is to be used with caution in cases of hypertension and when patients …

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• +BlockageWarning

  … ic lupus erythematosus and other connective tissue disorders (hepatic and renal function may be impaired in these conditions) • Thyrotoxicosis (may be exacerbated by large doses of salicylates) • Elderly patients are particularly susceptible to the adverse effects of NSAIDs, including acetylsalicylic acid especially gastrointestinal bleeding and perforation which may be fatal (see section 4.2). Where prolonged therapy is required, patients should be reviewed regularly. • Before commencing long-term aspirin therapy for the management of cardiovascular or cerebrovascular disease patients should consult their doctor who can advise on the relative benefits versus the …

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• +Serotonin effectsWarning

  … n with the use of acetylsalicylic acid (see section 4.8). Acetylsalicylic acid should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity. • Concomitant treatment with acetylsalicylic acid and other drugs that alter haemostasis (i.e. anticoagulants such as warfarin, thrombolytic and antiplatelet agents, anti-inflammatory drugs and selective serotonin reuptake inhibitors) is not recommended, unless strictly indicated, because they may enhance the risk of haemorrhage (see section 4.5). If the combination cannot be avoided, close observation for signs of bleeding is recommended. • Caution should be advised in patients receiving concomitant medications which could increase the risk of ulceration, such as oral corticosteroids, selective serotonin-reuptake inhibitors and defe …

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• +ThyroidWarning

  … n. Temporary discontinuation of treatment may be necessary. • Systemic lupus erythematosus and other connective tissue disorders (hepatic and renal function may be impaired in these conditions) • Thyrotoxicosis (may be exacerbated by large doses of salicylates) • Elderly patients are particularly susceptible to the adverse effects of NSAIDs, including acetylsalicylic acid especially gastrointestinal bleeding and perforation which may be fatal (see section …

  Source SmPC ↗
• +Gap needed after another medicineWarning

  … hydrated since the use of NSAIDs may result in deterioration of renal function. Liver function tests should be performed regularly in patients presenting slight or moderate hepatic insufficiency. • There is an increased risk of haemorrhage particularly during or after operative procedures (even in cases of minor procedures, e.g. tooth extraction). Use with caution before surgery, including tooth extraction. Temporary discontinuation of treatment may be necessary. • Systemic lupus erythematosus and other connective tissue disorders (hepatic and renal function may be impaired in these conditions) • Thyrotoxicosis (may be exacerbated by large doses of salicy …

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• +AlcoholInteraction

  … ead to decreased total phenytoin levels in plasma, but increased free phenytoin fraction. The unbound concentration, and thereby the therapeutic effect, does not appear to be significantly altered. Alcohol Concomitant administration of alcohol and acetylsalicylic acid increases the risk of gastrointestinal bleeding. Systemic corticosteroids The risk of gastrointestinal ulceration and bleeding may …

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• +Low blood pressureInteraction

  … e usually permanent. • Laboratory investigations - aspirin may interfere with some laboratory tests such as urine 5-hydroxyindoleacetic acid determinations and copper sulfate urine sugar tests. • Calcium-channel blockers – reduced hypotensive effects, increased antiplatelet effect which rarely results in pro-longed bleeding time. • Varicella vaccine - Vaccine recipients should avoid use of salicylates for 6 weeks after vaccination with varicella vaccine as Reye's syndrome has been reported following use of salicylates durin …

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• +InfectionInteraction

  … id determinations and copper sulfate urine sugar tests. • Calcium-channel blockers – reduced hypotensive effects, increased antiplatelet effect which rarely results in pro-longed bleeding time. • Varicella vaccine - Vaccine recipients should avoid use of salicylates for 6 weeks after vaccination with varicella vaccine as Reye's syndrome has been reported following use of salicylates during wild-type varicella infection (see section 4.4). • Ginkgo Biloba – possible increase in risk of bleeding. Contraindicated combinations Methotrexate (used at doses >15 mg/week): The combined drugs, methotrexate and acetylsalicylic acid, en …

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• +Acid build-up in the bloodInteraction

  … ration via decreased renal prostaglandin synthesis. Hydrating the patient and monitoring renal function at the start of the treatment is recommended. Carbonic anhydrase inhibitors (acetazolamide) May result in severe acidosis and increased central nervous system toxicity Ciclosporin, tacrolimus Concomitant use of NSAIDs and ciclosporin or tacrolimus may increase the nephrotoxic effect of ciclosporin and tacrolimus. The renal function should be monitored in case o …

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• +BreastfeedingPregnancy

  … n of uterine contractions resulting in delayed or prolonged labour. Consequently, acetylsalicylic acid at doses of 100 mg/day and higher is contraindicated during the third trimester of pregnancy. Lactation Low quantities of salicylates and of their metabolites are excreted into the breast milk. Adverse effects for the infant have not been reported up to now. However, aspirin should be avoided during …

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• +Azo colourants—Not in scanned sections

  Not found in the sections read for this label. Not the same as the label being silent.

• +Benzyl alcohol—Not in scanned sections

  Not found in the sections read for this label. Not the same as the label being silent.

• +Salt and mineral balance—Not in scanned sections

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• +Intolerance to an ingredient—Not in scanned sections

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• +Fertility—Not in scanned sections

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• +Lactose—Not in scanned sections

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• +Sodium and potassium content—Not in scanned sections

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• +Peanut—Not in scanned sections

  Not found in the sections read for this label. Not the same as the label being silent.

• +Propylene glycol—Not in scanned sections

  Not found in the sections read for this label. Not the same as the label being silent.

• +Soya—Not in scanned sections

  Not found in the sections read for this label. Not the same as the label being silent.

• +Blood clots—Not in scanned sections

  Not found in the sections read for this label. Not the same as the label being silent.