… s of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.
This medicine contains 12.35 mg propylene glycol (E1520) in each ml.
• Co-administration with any substrate for alcohol dehydrogenase such as ethanol may induce adverse effects in children less than 5 years old.
• While propylene glycol has not been shown to cause reproductive or developmental toxicity in animals or humans, it may reach the foetus and was found in milk. As a consequence, administration of …
Identical in both labels. Surrounding text shown from Morningside Healthcare Ltd.
Contains wheat starch. Suitable for people with coeliac disease. Patients with wheat allergy (different from coeliac disease) should not take this medicine.
Patients should abstain from alcohol for at least 48 hours following discontinuation of therapy with metronidazole. A disulfiram-like reaction with hypotension and flushing has occurred (see section 4.5).
Caution is advised in patients with porphyria.
Metronidazole tablets should not be used in patients with blood dyscrasias or with active non-infectious disease of the central nervous system. High d …
Identical in both labels. Surrounding text shown from Zentiva.
… ronidazole metabolites.
Sodium restricted patients:
This medicinal product contains 13.5 mmol (310 mg) sodium per 100 mL. To be taken into consideration by patients on a controlled sodium diet.
Alcohol:
Patients should be advised to discontinue consumption of alcoholic beverages or alcohol-containing products before, during, and up to 72 hours after taking metronidazole because of a disulfram-like …
… mity, have been reported in patients treated with metronidazole. The appearance of abnormal neurological signs demands the prompt evaluation of the benefit/risk ratio of the continuation of therapy.
Patients should be advised not to take alcohol during Metronidazole therapy and at least 48 hours afterwards because of a disulfram-like effect (flushing, vomiting, tachycardia).
In the case of severe hypersensitivity reactions (e.g. anaphylactic shock), treatment with Metronidazole 500 mg/100 ml Solution for Infusion must be discontinued immediately and established emergenc …
Patients are advised not to take alcohol during systemic metronidazole therapy because of the possibility of a disulfiram-like reaction.
Some potentiation of anti-coagulant therapy has been reported when metronidazole has been used with the warfarin type oral anticoagulants.
Patients receiving phenobarbitone metabolise metronidazole …
Interaction with systemic medication is unlikely because absorption of metronidazole following cutaneous application of Metrogel is low. Nevertheless, it should be mentioned that disulfiram-like reactions have been reported in a small number of patients taking metronidazole and alcohol concomitantly. Oral metronidazole has been reported to potentiate the effect of warfarin and other coumarin anticoagulants, resulting in a prolongation of prothrombin time. The effect of topical metronidazole on prothrombin is not known. However, very rare cases of modification of the INR values have been reported with concomitant use of Metrogel and coumarin anticoagulants.
Patients should be advised not to take alcohol during metronidazole therapy and for at least 48 hours afterwards because of the possibility of a disulfiram like (antabuse effect) reaction. Psychotic reactions have been reported in patients who were using metronidazole and disulfiram concurrently.
Some potentiation of anticoagulant therapy has been reported when metronidazole has been used with the warfarin type oral anticoagulants.
Dosage of the latter may require reducing. Prothrombin time …
… dosage adjusted accordingly, particularly following initiation or discontinuation of metronidazole therapy in patients who are stabilized on their tacrolimus regimen.
Other forms of interaction
Alcohol:
Intake of alcoholic beverages must be avoided during metronidazole therapy since adverse reactions such as dizziness and vomiting may occur (disulfiram-like effect).