… shock), treatment with Metronidazole 500 mg/100 ml Solution for Infusion must be discontinued immediately and established emergency treatment must be initiated by qualified healthcare professionals.
Severe persistent diarrhoea occurring during treatment or during the subsequent weeks may be due to pseudomembranous colitis (in most cases caused by Clostridioides difficile), see section 4.8. This intestinal disease, precipitated by the antibiotic treatment, may be life-threatening and requires immediate appropriate treatment. Anti-peristaltic medicinal products must not be given.
The duration of therapy with metronidazole or drugs containing other nitroimidazoles should not exceed 10 days. Only in specific elective cases and if definitely needed, the treatment period may be …
… anaphylactic shock; see also section 4.8), treatment with Metronidazole must be discontinued immediately and established emergency treatment must be initiated by qualified healthcare professionals.
Severe persistent diarrhoea occurring during treatment or during the subsequent weeks may be due to pseudomembranous colitis (in most cases caused by Clostridium difficile), see section 4.8. This intestinal disease, precipitated by the antibiotic treatment, may be life-threatening and requires immediate appropriate treatment.
Anti-peristaltic medicinal products must not be given.
The duration of therapy with metronidazole or drugs containing other nitroimidazoles should not exceed 10 days. Only in specific elective case …
… amiodarone, tacrolimus, cyclosporine, carbamazepine, and quinidine) may increase respective CYP3A4-substrate plasma levels. Monitoring of plasma concentrations of CYP3A4 substrates may be necessary.
Busulfan: Plasma concentrations of busulfan may increase during concomitant treatment with metronidazole, which can result in serious busulfan toxicity such as sinusoidal obstruction syndrome, gastrointestinal mucositis, and hepatic veno-occlusive disease.
Laboratory tests:
Metronidazole may immobilise Treponema and thus may lead to falsely positive Nelson's test.
Metronidazole may interfere with serum aspartate transaminase (AST), alanine transam …