• Known hypersensitivity to metronidazole or any of the ingredients in the tablets. • Pregnancy - metronidazole should not be used in the first trimester in patients with trichomoniasis or bacterial vaginosis (see section 4.6). • Breast feeding should be discontinued for 12-24 hours when single high dose (e.g. 2g) therapy is used (see section 4.6).
Identical in all 3 labels. Surrounding text shown from Zentiva.
… ains 12.35 mg propylene glycol (E1520) in each ml.
• Co-administration with any substrate for alcohol dehydrogenase such as ethanol may induce adverse effects in children less than 5 years old.
• While propylene glycol has not been shown to cause reproductive or developmental toxicity in animals or humans, it may reach the foetus and was found in milk. As a consequence, administration of propylene glycol to pregnant or lactating patients should be considered on a case by case basis.
• Medical monitoring is required in patients with impaired renal or hepatic functions because various adverse events attributed to propylene glycol have been reported such as renal dysfunction (acu …
Identical in both labels. Surrounding text shown from Morningside Healthcare Ltd.
Pregnancy
There has been no experience to date with the use of Metrogel in pregnant patients. In case of oral administration, metronidazole crosses the placental barrier and enters foetal circulation rapidly …
Identical in all 3 labels. Surrounding text shown from Galderma (U.K.) Limited.
The safety of topically applied metronidazole in pregnancy and lactation has not been adequately established and should not be used in these circumstances unless the physician considers it essential.
There is inadequate evidence of the safety of metronidazole in pregnancy but it has been in wide use for many years without apparent ill consequence.
Neverthless metronidazole, like other medicines, should not be given during pregnancy or during lactation unless the physician considers it essential; in these circumstances the short, high-dosage r …