… possibly reduce the contraceptive effect. • Drug-lab modifications: Aspartate amino transferase assays may give spuriously low values in patients taking metronidazole, depending on the method used. • Busulfan : Plasma levels of busulfan may be increased by metronidazole which may lead to severe busulfan toxicity. Drugs that prolong QT interval: QT prolongation has been reported, particularly when metronidazole was administered with drugs with potential for prolonging the QT interval.
… creatinine should be closely monitored when coadministration is necessary.
• Busulfan: Plasma levels of busulfan may be increased by metronidazole which may lead to severe busulfan toxicity.
• Drugs that prolong QT interval: QT prolongation has been reported, particularly when metronidazole was administered with drugs with the potential for prolonging the QT interval.
Interactions with other medicinal products
Drugs that prolong the QT interval
Prolongation of the QT interval has been reported, especially when metronidazole is administered to-gether with drugs that have the potential to prolong the QT interval. QT interval prolongation an …
Interactions to be used with caution:
Amiodarone:
QT interval prolongation and torsade de pointes have been reported with the co administration of metronidazole and amiodarone. It may be appropriate to monitor QT interval on the ECG if amiodarone is used in combination with metronidazole.
Patients treated on an outpatient basis should be advised to seek medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, palpitatio …