… istered simultaneously with aspirin, it is necessary to ensure adequate hydration of the patient and to monitor the kidney function and blood pressure, particularly when starting diuretic treatment.
Like other NSAIDs, concomitant use of aspirin with diuretics or antihypertensive agents (e.g., beta-blockers, angiotensin converting enzyme (ACE) inhibitors) may cause a decrease in their antihypertensive effect. Therefore, the combination should be administered with caution and patients, especially the elderly, should have their blood pressure periodically monitored. Patients should be adequately hydrated and consideration should be given to monitoring of renal function after initiation of concomitant therapy and periodically thereafter, particularly for diuretics and ACE inhibitors, due to the increased risk of nephrotoxicity. Concomitant treatment with potassium-sparing drugs may be associated with increased serum potassium levels, which should therefore be monitored frequently.
Anticoagulants: Aspirin may enhance the effects of oral anticoagulants, such as heparin and coumarins, and of platelet aggregation inhibitors, such as ticlopidine, clopidogrel, and cilostazol, as th …
Identical in both labels. Surrounding text shown from Haleon UK Trading Limited.