… e been reported in patients with depleted glutathione levels, such as those who are severely malnourished, anorexic, have a low body mass index or are chronic heavy users of alcohol or have sepsis.
In patients with glutathione depleted states, the use of paracetamol may increase the risk of metabolic acidosis.
Keep out of sight and reach of children
Should be used with caution in elderly patients who are more prone to adverse events.
The concomitant use of aspirin with other systemic NSAIDs, including c …
Identical in both labels. Surrounding text shown from Haleon UK Trading Limited.
… th glucose 6-phosphate dehydrogenase (G6PD) deficiency.
Aspirin should be used with caution in patients with impaired renal or hepatic function (avoid if severe), or in patients who are dehydrated.
Nu-seals 300mg contains benzyl alcohol. High volumes should be used with caution and only if necessary, especially in patients with liver or kidney impairment because of the risk of benzyl alcohol accumulation and toxicity (metabolic acidosis). Benzyl alcohol may also cause allergic reactions.
Patients with hypertension should be carefully monitored.
Nu-Seals should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity.
There is som …
… reatment is recommended.
Patients concomitantly treated with verapamil and acetylsalicylic acid should be carefully monitored for signs of bleeding.
Carbonic anhydrase inhibitors (acetazolamide)
May result in severe acidosis and increased central nervous system toxicity.
Systemic corticosteroids
The risk of gastrointestinal ulceration and bleeding may be increased when acetylsalicylic acid and corticosteroids are co-administered (see section 4.4).
Methotrexate …
Identical in both labels. Surrounding text shown from G.L Pharma UK Limited.
… ration via decreased renal prostaglandin synthesis. Hydrating the patient and monitoring renal function at the start of the treatment is recommended.
Carbonic anhydrase inhibitors (acetazolamide)
May result in severe acidosis and increased central nervous system toxicity
Ciclosporin, tacrolimus
Concomitant use of NSAIDs and ciclosporin or tacrolimus may increase the nephrotoxic effect of ciclosporin and tacrolimus. The renal function should be monitored in case o …
… ons.
Uricosurics: Acetylsalicylic acid may inhibit the effects of uricosurics.
Mifepristone: NSAIDs can reduce the effect of mifepristone.
Methotrexate: Decreased elimination of methotrexate.
Carbonic anhydrase inhibitors e.g. Acetazolamide: May result in severe acidosis and increased central nervous system toxicity.
Metamizole: Metamizole may reduce the effect of acetylsalicylic acid on platelet aggregation when taken concomitantly. Therefore, this combination should be used with caution in patients taking low …
Acid build-up in the blood · Aspirin · Interchangeable?