… , angioedema, urticaria, or acute rhinitis are precipitated by aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs).
- Peptic ulceration and those with a history of peptic ulceration;
- History of upper gastrointestinal bleeding or perforation, related to previous NSAID therapy.
- History of hemophilia, hypothrombinemia or other clotting disorders
- Renal failure (GFR < 15mL/min/1.73m2).
- Hepatic failure.
- Third trimester of pregnancy
children under 16 years and when …
Identical in both labels. Surrounding text shown from Haleon UK Trading Limited.
… cially non-steroidal anti-inflammatory drugs (NSAIDs) A history of asthma caused by salicylates or substances with a similar mechanism of action, especially NSAIDs; - Acute gastrointestinal ulcers; - A history of gastrointestinal bleeding or perforation (gastric or intestinal failure) caused by previous NSAID therapy; - Active or a history of recurrent gastric and duodenal ulcer/haemorrhage with episodes of proven ulceration or bleeding, or other kinds of bleeding such as cerebrovascular haemorrhages; - Haemorrhag …
… sociation with the use of acetylsalicylic acid (see section 4.8). Aspirin tablets should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity.
Elderly patients are particularly susceptible to the adverse effects of NSAIDs, including acetylsalicylic acid especially gastrointestinal bleeding and perforation which may be fatal (see section 4.2). Where prolonged therapy is required, patients should be reviewed regularly.
Concomitant treatment with Aspirin and other drugs that alter haemostasis (i.e. anticoagulants such as warfarin, thrombolytic and antiplatelet agents, anti-inflammatory drugs and selective serotonin …
Identical in both labels. Surrounding text shown from Dexcel Pharma Ltd.
… stinal effects: NSAIDs should be given with care to patients with a history of gastrointestinal disease (ulcerative colitis, Crohn's disease) as their condition may be exacerbated (see section 4.8).
Gastrointestinal bleeding, ulceration or perforation which can be fatal, has been reported with all NSAIDs at any time during treatment, with or without warning symptoms or a previous history of serious GI events.
The risk of GI bleeding, ulceration or perforation is higher with increasing NSAID doses, in patients with a history of ulcer, particularly if complicated with haemorrhage or perforation and in the …