… reverse the effect of probenecid and sulfinpyrazone. The combination should be avoided.
Combinations requiring precautions for use or to be taken into account
Anticoagulants and thrombolytics
Acetylsalicylic acid may increase the effects of thrombolytic agents. Increased risk of bleeding due to inhibited thrombocyte function, injury of the duodenal mucosa and displacement of oral anticoagulants from their plasma protein binding sites. Patients that are treated concomitantly with acetylsalicylic acid and other antithrombotic agents should be carefully monitored for signs of bleeding (see section 4.4).
Particularly, treatment with acetylsalicylic acid should not be initiated within the first 24 hours after treatment with alteplase in acute stroke patients.
Anti-platelet agents (e.g clopidogrel, …